Prioritizing Stability-enhancing Mutations using a Protein Language Model in conjunction with Physics-Based Predictions
Emily R. Rhodes, Guido Scarabelli, Jonathan Jou, Jacob Byerly, Kayla G. Sprenger, Eliud O. Oloo
The paper combines a protein language model and physics-based method to prioritize stability-enhancing mutations, achieving higher accuracy than either method alone.
bioRxiv · Oct 28, 2025 · PreprintBiophysics