Jonathan Jou

This paper introduces a coarse-grained simulation method to predict the viscosity of antibody solutions and their response to excipients.

The paper combines a protein language model and physics-based method to prioritize stability-enhancing mutations, achieving higher accuracy than either method alone.

The paper identifies four novel genetic variants associated with IPF survival, including a PCSK6 variant, and suggests PCSK6 as a prognostic biomarker and therapeutic target.

OSPREY 3.0 improves protein design software with faster algorithms, GPU support, and a Python interface, showing accurate mutation effect predictions on protein-protein binding.