Author

Jacob Byerly

Schrodinger (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Eliud O. OlooiD· 1 shared Emily R. Rhodes· 1 shared Guido Scarabelli· 1 shared Jonathan JouiD· 1 shared Kayla G. SprengeriD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

Eliud O. OlooORCID

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1 paper

Recent·Most cited

Prioritizing Stability-enhancing Mutations using a Protein Language Model in conjunction with Physics-Based Predictions

Emily R. Rhodes, Guido Scarabelli, Jonathan Jou, Jacob Byerly, Kayla G. Sprenger, Eliud O. Oloo

The paper combines a protein language model and physics-based method to prioritize stability-enhancing mutations, achieving higher accuracy than either method alone.

bioRxiv · Oct 28, 2025 · PreprintBiophysics