Author

Guihua Zhang

First Affiliated Hospital of Guangzhou Medical UniversityPrimary ORCID profile (0000-0002-4599-418X · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Guihua ZhangiD3 papers · Guangzhou University

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:graph neural network· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Anqi ZhouiD· 1 shared Bao Xue· 1 shared Hongming CheniD· 1 shared Hua CheniD· 1 shared Jiayi Chen· 1 shared Jielin TangiD· 1 shared Jinpeng Zhong· 1 shared Jinsai ShangiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Anqi ZhouORCID

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1 paper

Recent·Most cited

Discovery of resistance-resilient quinoline papain-like protease inhibitors through topology-constrained molecular generative design

Yongzhi Lu, Ting Ran, Qi Yang, Guihua Zhang, Jiayi Chen, Peiqi Zhou, Wenqi Li, Minyuan Xu, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, , Jinsai Shang

This paper discovers a novel quinoline-based PLpro inhibitor, GZNL-2016, that remains effective against drug-resistant SARS-CoV-2 variants like Omicron BA.5 and XBB.1.

bioRxiv · Sep 7, 2024 · PreprintMicrobiology