MicrobiologybioRxivPreprint
Discovery of resistance-resilient quinoline papain-like protease inhibitors through topology-constrained molecular generative design
Yongzhi Lu, Ting Ran, Qi Yang…·Jinsai Shang
This paper discovers a novel quinoline-based PLpro inhibitor, GZNL-2016, that remains effective against drug-resistant SARS-CoV-2 variants like Omicron BA.5 and XBB.1.
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