Beyond signaling activation: Phosphorylation modulates Grb2 phase separation to create multivalent scaffolds
R. G. S. Dias, Carolina Boschi Gimenes, Aline Sebastiane de Oliveira, Guilherme Fusari, Sebastião Roberto Taboga, Antonio Jose Costa-Filho, Fernando A. Melo
This study shows phosphorylation of Grb2 drives phase separation, forming scaffolds that recruit and sequester wild-type dimers, redefining Grb2's role in signaling.
bioRxiv · Mar 8, 2026 · PreprintBiophysics