Sex differences in colonic inflammation are driven by epithelial-specific expression of estrogen receptor alpha
Guillermo A. Pereda, Adrian D Kocinski, Alyssia V. Broncano, Sarah K McNeer, Michelle Raymond, Nicholas P. Ziats, Keith A. Breau, Joseph Burclaff, Scott T. Magness, Wendy A. Goodman
This study shows that deleting estrogen receptor alpha in colonic epithelial cells protects female mice from inflammation but causes hyper-proliferation in males.
Gastro Hep Advances · Jan 1, 2025Peer-reviewedCell Biology