Wendy A. Goodman

Platelets regulate glioblastoma growth and immunity via sex-dependent PAR4 - Estrogen receptor beta signaling

This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.

Rethinking the Estrogen Receptor Beta Dominance Hypothesis in Endometriosis: Insights from Single Cell RNA Sequencing Meta-analysis

This study challenges the ER{beta} dominance hypothesis by showing no significant ER{beta} dominance in endometriosis tissues and highlighting cell- and tissue-specific roles of estrogen receptor isoforms.

ERb limits T cell-mediated inflammation to maintain immune homeostasis

This study shows that ER{beta} in CD4+ T cells suppresses inflammation by limiting proliferation and Th1 polarization, thereby maintaining immune homeostasis.

Sex differences in colonic inflammation are driven by epithelial-specific expression of estrogen receptor alpha

This study shows that deleting estrogen receptor alpha in colonic epithelial cells protects female mice from inflammation but causes hyper-proliferation in males.