Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation
Baohua Tan, Linjun Hong, Liyao Xiao, Jiajin Wu, Guobin Lu, Shanshan Wang, Langqing Liu, Enqin Zheng, Gengyuan Cai, Zicong Li, Ting Gu, Zhenfang Wu
This study identifies how 3D chromatin topology and enhancer-promoter interactions drive transcriptional changes in muscle fiber-type specification and transformation.
Nature Communications · Jul 1, 2025Peer-reviewedDevelopmental Biology