Shanshan Wang

This study identifies how 3D chromatin topology and enhancer-promoter interactions drive transcriptional changes in muscle fiber-type specification and transformation.

This study shows APP induces reactive astrogliosis in vitro and in vivo by remodeling intermediate filaments, enhancing cytokine production, and activating the IFN pathway.

This study identifies FOXA2's role in maintaining urea cycle function in acute liver failure by regulating CPS1 transcription and preventing hyperammonemia.

This paper identifies GLT8D1 mutations as a cause of ALS by disrupting neurotrophin signaling in lipid rafts through reduced ganglioside expression.

This study shows that suppressing miR-199a-5p reduces ulcerative colitis by increasing XBP1 expression through endoplasmic reticulum stress.

This study shows that re-expressing caveolin-1 in Alzheimer's disease mice improves cognitive function and reduces neurodegeneration without affecting amyloid deposits.