Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.
Guohua Lv, Nicole M. Sayles, Yun T. Huang, Chiara D. Mancinelli, Kevin McAvoy, Neil A. Shneider, Giovanni Manfredi, Hibiki Kawamata, David Eliezer
The paper identifies amyloid fibril structures of CHCHD10 and links them to neurodegeneration, showing sequence differences between CHCHD10 and CHCHD2 allow co-aggregation.
Nature Communications · Aug 2, 2025Peer-reviewedBiophysics