Nicole M. Sayles

Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.

The paper identifies amyloid fibril structures of CHCHD10 and links them to neurodegeneration, showing sequence differences between CHCHD10 and CHCHD2 allow co-aggregation.

High fat diet ameliorates the mitochondrial cardiomyopathy of CHCHD10 mutant mice

This study shows that a high fat diet improves mitochondrial cardiomyopathy in CHCHD10 mutant mice by enhancing fatty acid utilization and reducing protein aggregation.

Comparative multi-omics analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency

The paper compares multi-omics data from three mouse models of partial frataxin deficiency to assess mitochondrial stress in the heart, finding mild transcriptional changes despite severe FXN reduction.

BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoids

This study uses patient-derived cerebral organoids to identify molecular and cellular mechanisms of Schizophrenia, revealing altered neuronal programming factors and growth factors like BRN2 and PTN.