The X-Linked Intellectual Disability gene, ZDHHC9, is important for oligodendrocyte subtype determination and myelination
Rocio Hollman, Angela R. Wild, Timothy P. O’Leary, Andrew J. Thompson, Stéphane Flibotte, Tashana O. Poblete, Angie Peng, Jason C. Rogalski, Gurmaan Gill, Shernaz Xerxes Bamji
This study shows that ZDHHC9 loss in mice disrupts oligodendrocyte subtypes and myelination, linking it to white matter deficits in XLID.
bioRxiv · Aug 8, 2023 · PreprintNeuroscience