Shernaz Xerxes Bamji

This study shows that loss of brain insulin production in female mice impairs learning and memory, while having no effect on males.

This study identifies ZDHHC9 as a key regulator of oligodendrocyte morphology and myelination, showing its role in palmitoylation of MBP and its impact on XLID.

This study shows that ZDHHC9 loss in mice disrupts oligodendrocyte subtypes and myelination, linking it to white matter deficits in XLID.

This study shows that synaptic activity affects post-translational modifications of palmitoylating enzymes but not depalmitoylating enzymes in the hippocampus.

This study identifies differentially palmitoylated proteins in the mouse hippocampus after fear conditioning and shows that palmitoylation of PRG-1/LPPR4 is essential for synapse plasticity.

The paper curates RNA-seq data of palmitoylating and de-palmitoylating enzymes in the mouse brain and identifies region and cell-type specific expression patterns.

This study shows Zdhhc5 is essential for forming excitatory synapses and its loss leads to synaptic deficits in mice.

The paper evaluates 106 PTEN variants using 18 assays across 5 models to identify molecular mechanisms of dysfunction, finding that stability and domain-specific assays are critical for accurate impact assessment.