Jason C. Rogalski

This study identifies cathepsin K-generated spliced peptides as potential autoantigens in RA, compatible with HLA-DR4 presentation.

This study compares functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in high and low insulin production states, revealing differences in resilience and protein machinery.

The paper uses tissue-resolved proteomics to analyze how pesticide and pathogen stressors affect honey bee tissues across crop ecosystems, finding stable tissue-specific patterns and crop-associated changes.

GIRAFI improves sparse single-cell proteomics by imputing missing values and revealing cell states using graph-informed statistical learning, outperforming existing methods and recovering biological structure.

The paper introduces a cost-effective single-cell proteomics workflow and a data evaluation framework to improve data quality and biological interpretability.

This paper demonstrates that lysosomal cysteine cathepsins can generate fusion peptides through reverse proteolysis, revealing a new dimension of protease activity and peptide diversification.

This study shows that PDK1 regulates triacylglycerol turnover in cardiomyocytes under nutrient deprivation, independent of its role in glucose metabolism.

The paper identifies Ins2 gene activity states in beta cells and shows that cAMP activators drive transitions between these states.

This study shows that β-hydroxybutyrate (βHB) increases insulin secretion and decreases glucagon secretion in human and mouse islets at physiological glucose concentrations.

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

This study shows that ZDHHC9 loss in mice disrupts oligodendrocyte subtypes and myelination, linking it to white matter deficits in XLID.

The paper identifies protein biomarkers for spinal cord injury severity and recovery using proteomic analysis of human and porcine samples, showing high predictive accuracy.