Single-cell profiling reveals stromal niche and α5β1 regulation of neutrophil phenotypes in ulcerative colitis
Yuxi Zhou, Jorge Canas, Jiayu Ye, Jacqueline N. Hoang, Sonia Ferkel-Soltau, Derek Holman, Raoul S. Sojwal, Touran Fardeen, Gustavo Vazques, Yuting Huang, Kathryn Peterson, Garry P. Nolan, Sidhartha R. Sinha, Stephan Rogalla, John Mark B. Gubatan
This study uses single-cell RNA sequencing and spatial profiling to show fibroblasts influence neutrophil inflammation in UC, with 5β1 targeting reducing inflammatory responses.
bioRxiv · Sep 23, 2026 · PreprintImmunology