Computational redesign of TALE proteins for DNA-templated assembly of protein fibers
Robbert J. de Haas, Mark D. Langowski, Andrew J. Borst, Visakh V. S. Pillai, Gwendolyn E. Hoffmann, Martin Bongers, Matthias Mulder, Suna Cheng, Catherine Treichel, Elizabeth M. Leaf, Mengyu Wu, Eric M. Lynch, Justin M. Kollman, Francesco Simone Ruggeri, Carl Walkey, , Neil P. King
The paper redesigns TALE proteins to assemble linear protein-DNA complexes on double-stranded DNA templates, enabling controlled length and application in antigen display.
Nature Communications · May 19, 2026Peer-reviewedBiochemistry