Mark D. Langowski

Lymphatic networks enable diversification of B cell responses to vaccines

This study shows that lymphatic networks create spatially distinct environments in draining lymph nodes that influence B cell differentiation, affinity selection, and antibody isotype, which can be manipulated through vaccine design.

Dysfunctional memory B cell responses to the protective repeat region of the Plasmodium circumsporozoite protein are associated with waning humoral immunity

The paper shows that the repetitive structure of the Plasmodium CSP protein affects B cell memory, leading to reduced humoral immunity over time.

Computational redesign of TALE proteins for DNA-templated assembly of protein fibers

The paper redesigns TALE proteins to assemble linear protein-DNA complexes on double-stranded DNA templates, enabling controlled length and application in antigen display.

Mannosylated nanoparticle immunogens enhance the circumsporozoite protein-specific B cell response and improve protection against sporozoite challenge

This study shows that nanoparticle vaccines with oligomannose glycans boost B cell responses and protection against malaria sporozoites compared to other glycan types.