Rapid and dynamic reprogramming within the tumor microenvironment drives EDA-CAR-T dysfunction and compromised therapeutic efficacy in solid tumors
Rodrigo A Redondo-Frutos, Pedro Justicia-Lirio, María Eréndira Calleja-Cervantes, Patxi San Martín‐Úriz, Paula Aguirre-Ruiz, Lorea Jordana-Urriza, Maider Garnica-Suberviola, Sergio Camara-Peña, Diego Alignani, Aitziber López, Saray Rodríguez-Diaz, Rebeca Martínez-Turrillas, Marta Gorraiz, Derya Bakırdöğen, Arianna Pocaterra, , Juan R. Rodríguez-Madoz
This study uses single-cell RNA sequencing to analyze EDA-CAR-T cell dynamics in the tumor microenvironment, revealing temporal reprogramming toward dysfunction and identifying immunosuppressive pathways that impair therapeutic efficacy in solid tumors.
bioRxiv · May 3, 2026 · PreprintGenomics