Saray Rodríguez-Diaz

Rational engineering of sdAb-based CAR T cells targeting BCMA enhances antitumor efficacy and persistence in Multiple Myeloma

This study engineers sdAb-based CAR T cells targeting BCMA, showing improved antitumor efficacy and persistence in multiple myeloma compared to existing therapies.

Rapid and dynamic reprogramming within the tumor microenvironment drives EDA-CAR-T dysfunction and compromised therapeutic efficacy in solid tumors

This study uses single-cell RNA sequencing to analyze EDA-CAR-T cell dynamics in the tumor microenvironment, revealing temporal reprogramming toward dysfunction and identifying immunosuppressive pathways that impair therapeutic efficacy in solid tumors.

Single-Cell Multiomics Reveals Regulatory Mechanisms of CAR T Cell Persistence and Dysfunction in Multiple Myeloma

This study uses single-cell multiomics to analyze CAR T cell dynamics in multiple myeloma, identifying regulatory mechanisms affecting persistence and dysfunction.