GenomicsbioRxivPreprint
Rapid and dynamic reprogramming within the tumor microenvironment drives EDA-CAR-T dysfunction and compromised therapeutic efficacy in solid tumors
Rodrigo A Redondo-Frutos, Pedro Justicia-Lirio, María Eréndira Calleja-Cervantes…·Juan R. Rodríguez-Madoz
This study uses single-cell RNA sequencing to analyze EDA-CAR-T cell dynamics in the tumor microenvironment, revealing temporal reprogramming toward dysfunction and identifying immunosuppressive pathways that impair therapeutic efficacy in solid tumors.