Simulated ischemia in live cerebral slices is mimicked by opening the Na+/K+ pump: clues to the generation of spreading depolarization.
Danielle H.J. Kim, Peter J. Gagolewicz, Sydney Amelia McQueen, H Latour, Kaitlyn A. Tresidder, Cathryn R. Jarvis, R. David Andrew
The paper shows that palytoxin mimics ischemia-induced spreading depolarization in brain slices by activating the Na+/K+ pump, suggesting a potential therapeutic target for ischemic brain injury.
Journal of Neurophysiology · May 7, 2025Peer-reviewedNeuroscience