A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species-specificity
J. S. Takeuchi, K. Fukano, M. Iwamoto, S. Tsukuda, R. Suzuki, H. Aizaki, M. Muramatsu, T. Wakita, C. Sureau, K. Watashi
The paper shows a single mutation in the NTCP receptor determines HBV infection specificity by showing how virus-induced positive selection at aa 158 alters host susceptibility.
bioRxiv · Aug 20, 2018Evolutionary Biology