R. Suzuki

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.

Characterizing medaka visual features using a high-throughput optomotor response assay

This study develops a high-throughput optomotor response assay in medaka larvae to quantify visual traits and detect strain-specific differences.

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

This study investigates the virological characteristics of the SARS-CoV-2 BA.2.86 variant, finding it has higher reproduction number than EG.5.1 but lower pathogenicity and replication capacity compared to BA.2.

Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

Importin-7-dependent nuclear localization of the Flavivirus core protein is required for infectious virus production.

This study identifies importin-7 as a nuclear carrier for Flaviviridae core proteins and shows its requirement for infectious virus production.

NEDD4-binding protein 1 suppresses HBV replication by degrading HBV RNAs

This paper identifies N4BP1 as a host factor that suppresses HBV replication by degrading HBV RNAs, with its KH-like and RNase domains required for this effect.

Spatio-temporal Coordination of Active Deformation Forces and Wnt / Hippo-Yap Signaling in Hydra Regeneration

The paper investigates how Wnt signaling and tissue deformation coordinate during Hydra regeneration, finding that biomechanical symmetry breaking is regulated by Wnt and stabilized by Hippo-Yap signaling.

GPR35 inhibits TRPA1-mediated colonic afferent hypersensitivity through suppression of Substance P release

This paper identifies GPR35 as a target for non-opioid analgesics by showing it inhibits TRPA1-mediated colonic hypersensitivity through suppression of Substance P release.

Virological characteristics of the SARS-CoV-2 XBB.1.5 variant

The paper analyzes the virological characteristics of the SARS-CoV-2 XBB.1.5 variant, showing reduced pathogenicity and impaired MHC expression due to mutations in ORF8 and S.

Neutralizing antibody responses and cellular responses against severe acute respiratory syndrome coronavirus 2 omicron subvariant BA.5 after an mRNA severe acute respiratory syndrome coronavirus 2 vaccine dose in kidney transplant recipients

This study evaluates antibody and cellular immune responses in kidney transplant recipients after three mRNA vaccine doses, finding lower neutralizing titers and T cell responses compared to healthy controls.

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

This study identifies XBB as a SARS-CoV-2 variant resulting from recombination of BA.2 subvariants, showing increased resistance to neutralizing antibodies and enhanced fusogenicity compared to BA.2.75.

Convergent evolution of the SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

The paper investigates convergent evolution in SARS-CoV-2 Omicron subvariants, identifying five critical spike protein substitutions in BQ.1.1 that enhance viral fitness and antibody resistance.

Deletion or inhibition of PTPRO mitigates diet-induced hepatic steatosis and inflammation in obesity

This study shows that deleting or inhibiting PTPRO reduces hepatic steatosis and inflammation in obese mice, improving metabolic health.

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

This study compares the pathogenicity of SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.5, finding BA.5 is more fusogenic and induces stronger inflammation than earlier variants.

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology

This study shows that an intranasal vaccine with CpG ODN2006 induces secretory IgA antibodies against SARS-CoV-2 variants and reduces lung eosinophilic immunopathology compared to subcutaneous vaccination.

Characterization of various remdesivir-resistant mutations of SARS-CoV-2 by mathematical modeling and molecular dynamics simulation.

This study identifies remdesivir-resistant SARS-CoV-2 mutations using viral reconstruction, mathematical modeling, and molecular dynamics simulations, showing mutations reduce antiviral activity without increasing viral production.

Virological characteristics of SARS-CoV-2 BA.2 variant

This study compares the virological characteristics of SARS-CoV-2 BA.2 and BA.1 variants, finding BA.2 has higher transmissibility, different antigenicity, greater replicative capacity, and higher pathogenicity in hamsters.

SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory amino acid differences and novel oncoprotein candidates

This study uses GWAS to identify genetic variations in H. pylori strains associated with gastric cancer and duodenal ulcers, revealing amino acid differences and novel oncoprotein candidates.

Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction

This study develops a PCR-based reverse genetics system for SARS-CoV-2 using CPER to generate infectious clones with high accuracy and titer.

Deep Texture Representations as a Universal Encoder for Pan-cancer Histology

This paper introduces deep texture representations (DTRs) as a universal encoder for cancer histology, enabling accurate prediction of genomic features and cancer types from histological images.

A high fat containing chicken egg-only diet suppresses fatty liver induced by a lipid-rich methionine and choline deficient diet.

This study compares the effects of a high-fat diet and an egg-only diet on NAFLD development in mice, finding that the egg-only diet suppresses fatty liver.

Structural basis for ligand-induced inactivation of protein tyrosine receptor type Z (PTPRZ): Physiological relevance of head-to-toe RPTP dimerization

This study reveals that PTN-induced inactivation of PTPRZ occurs through head-to-toe dimerization of its tandem PTP domains, which is critical for OPC differentiation.

A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species-specificity

The paper shows a single mutation in the NTCP receptor determines HBV infection specificity by showing how virus-induced positive selection at aa 158 alters host susceptibility.