M. Muramatsu

Byproducts of inflammatory radical metabolism provide transient nutrient niches for microbes in the inflamed gut

The paper investigates how inflammatory radicals generate tartaric acid isomers, which serve as transient nutrients for gut pathogens in murine models.

Evasion of APOBEC1-mediated Intrinsic Immunity by a Herpesvirus Uracil DNA Glycosylase Is a Determinant of Viral Encephalitis

This study shows that HSV-1's vUNG enzyme evades APOBEC1 immunity by preventing DNA editing, leading to more severe encephalitis in mice.

Inhibitory effect of Ephedra herba on human norovirus infection in human intestinal organoids

This study screens Kampo crude drugs for anti-HuNoV effects using human intestinal organoids, identifying Ephedra herba as a novel inhibitor targeting the post-entry step of infection.

Prediction of elimination of intrahepatic cccDNA in hepatitis B virus-infected patients by a combination of noninvasive viral markers

This study develops a noninvasive method using viral markers to predict cccDNA levels in HBV patients, validated against liver biopsy data.

Evaluation of heat inactivation of human norovirus in freshwater clams using human intestinal enteroids

This study evaluates heat inactivation of human norovirus in freshwater clams using human intestinal enteroids, finding that 1 minute at 90°C inactivates the virus.

The kinesin KIF4 mediates HBV/HDV entry through regulation of surface NTCP localization and can be targeted by RXR agonists in vitro.

This paper identifies KIF4 as a critical regulator of NTCP surface localization for HBV/HDV entry and shows RXR agonists can suppress KIF4 to inhibit viral infection.

Dasabuvir inhibits human norovirus infection in human intestinal enteroids

This study identifies dasabuvir as an anti-HuNoV inhibitor using human intestinal enteroids, showing activity against HuNoV, SARS-CoV-2, and RVA.

The 3' end of the human norovirus antigenomic sequence is required for its genomic RNA synthesis by RNA-dependent RNA polymerase

This study identifies the 3' end stem-loop structure of the human norovirus antigenomic sequence as essential for RdRp-mediated genomic RNA synthesis.

Identification of anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) oxysterol derivatives in vitro

This study identifies oxysterol derivatives with anti-SARS-CoV-2 activity, showing that Oxy210 and Oxy232 inhibit viral replication by disrupting double membrane vesicles.

Anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) potency of Mefloquine as an entry inhibitor in vitro

This study identifies Mefloquine as a potent in vitro entry inhibitor of SARS-CoV-2 with higher antiviral activity than Hydroxychloroquine.

MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter

This study identifies MafF as an antiviral host factor that suppresses HBV core promoter transcription, contributing to host defense against HBV infection.

Multidrug treatment with nelfinavir and cepharanthine against COVID-19

This study identifies a new multidrug combination treatment for COVID-19 using nelfinavir and cepharanthine, showing synergistic antiviral effects and improved disease control.

A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species-specificity

The paper shows a single mutation in the NTCP receptor determines HBV infection specificity by showing how virus-induced positive selection at aa 158 alters host susceptibility.