The carboxyl-terminal sequence of Bim enables Bax activation and killing of unprimed cells
X. Chi, J. Pemberton, D. Nguyen, E. J. Osterlund, Q. Liu, H. Brahmbhatt, Z. Zhang, J. Lin, B. Leber, D. Andrews
This study shows that the carboxyl-terminal sequence of Bim is necessary for Bax activation and cell killing, independent of anti-apoptotic protein inhibition.
bioRxiv · Feb 19, 2019Biochemistry