Author

D. Andrews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:imaging· 2

Frequent Co-Authors

A. Terskikh· 2 shared B. Leber· 2 shared C. Farhy· 2 shared C. Forsberg· 2 shared C.-T. Huang· 2 shared D. Nguyen· 2 shared E. J. Osterlund· 2 shared F. Ugarte· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

A. Terskikh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes.

J. M. Pemberton, E. J. Osterlund, W. Schoormann, J. Pogmore, D. Nguyen, B. Leber, D. Andrews

This study identifies a novel binding site in PUMA's carboxyl-terminal sequence that contributes to its resistance to BH3-mimetic displacement from anti-apoptotic proteins.

bioRxiv · Apr 2, 2023Cell Biology

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

B. Boast, K. Helian, D. Andrews, X. Li, V. Cho, A. Closa, H. J. Sutton, J. H. Reed, H. Bergmann, C. M. Roots, M. Yabas, N. Barthel, S. A. Omari, C. Young, L. A. Miosge, , A. Enders

Reduced PAX5 function in mice leads to uncommitted B cell development and B-ALL with secondary mutations in Jak3 and Ptpn11.

bioRxiv · Jan 29, 2021 · PreprintImmunology

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

H. J. Sutton, R. Aye, A. H. Idris, R. Vistein, E. Nduati, O. Kai, J. Mwacharo, L. Xi, X. Gao, D. Andrews, M. Koutsakos, T. H. O. Nguyen, M. Nekrasov, P. Milburn, A. Ethala, , I. A. Cockburn

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

bioRxiv · May 28, 2020 · PreprintImmunology

Improving drug discovery using image-based multiparametric analysis of epigenetic landscape.

C. Farhy, S. Hariharan, J. Ylanko, L. Orozco, F.-Y. Zeng, I. Pass, F. Ugarte, C. Forsberg, C.-T. Huang, D. Andrews, A. Terskikh

This paper introduces MIEL, an image-based method for epigenetic drug screening, showing it can detect active compounds, classify functions, and predict novel drug effects with higher resolution than traditional methods.

bioRxiv · May 15, 2019Cell Biology

The carboxyl-terminal sequence of Bim enables Bax activation and killing of unprimed cells

X. Chi, J. Pemberton, D. Nguyen, E. J. Osterlund, Q. Liu, H. Brahmbhatt, Z. Zhang, J. Lin, B. Leber, D. Andrews

This study shows that the carboxyl-terminal sequence of Bim is necessary for Bax activation and cell killing, independent of anti-apoptotic protein inhibition.

bioRxiv · Feb 19, 2019Biochemistry

Multiparametric Signature of Glioblastoma Differentiation Revealed by Imaging of Cellular Epigenetic Landscapes

C. Farhy, S. Hariharan, J. Ylanko, L. van Woudenberg, F. Cimadamore, F. Ugarte, C. Forsberg, C.-T. Huang, D. Andrews, A. Terskikh

The paper develops MIEL, an imaging method to identify epigenetic signatures of differentiated glioblastoma cells and validates its use in selecting small molecules that induce tumor-propagating cell differentiation.

bioRxiv · Aug 16, 2018 · PreprintCancer Biology