A physiology-based model of bile acid metabolism shows altered tissue concentrations after drug administration and in specific genotype subgroups
Vanessa Baier, H. Cordes, Christoph Thiel, Ulf P. Neumann, Lars M. Blank, Lars Kuepfer
The paper develops a physiology-based model of bile acid metabolism to predict drug-induced liver injury risk and genetic susceptibility.
bioRxiv · Oct 24, 2018 · PreprintSystems Biology