The paper shows that tumors drive the accumulation of GATA3-dependent effector tissue Tregs through TCR-dependent oligoclonal expansion, promoting tumor growth.

bioRxiv · Mar 15, 2026 · PreprintImmunology

Microbially-conjugated Bile Salts Found in Human Bile Activate the Bile Salt Receptors TGR5 and FXR.

Ümran Ay, Martin Leníček, Raphael Silvanus Haider, Arno Claßen, Hans M.H. van Eijk, Kiran V.K. Koelfat, Gregory van der Kroft, Ulf P. Neumann, Carsten Hoffmann, Carsten Bolm, Steven W.M. Olde Damink, Frank G. Schaap

The paper identifies microbial bile salt conjugates that activate TGR5 and FXR receptors in human systems and quantifies their presence in blood and bile.

Hepatology Communications · Mar 22, 2024Peer-reviewedMolecular Biology

An optimized workflow for analyzing extracellular vesicles as biomarkers in liver diseases.

Martha Paluschinski, Sven Heiko Loosen, Claus Kordes, Verena Keitel, Anne Kuebart, Timo Brandenburger, David Schöler, Marianne Wammers, Ulf P. Neumann, Tom Luedde, Mirco Castoldi

This paper presents an optimized workflow for isolating and analyzing extracellular vesicles from plasma and serum in liver diseases, identifying miRNAs and cytokines as potential biomarkers.

International Journal of Molecular Sciences · Jun 1, 2023Peer-reviewedMolecular Biology

A physiology-based model of bile acid metabolism shows altered tissue concentrations after drug administration and in specific genotype subgroups

Vanessa Baier, H. Cordes, Christoph Thiel, Ulf P. Neumann, Lars M. Blank, Lars Kuepfer

The paper develops a physiology-based model of bile acid metabolism to predict drug-induced liver injury risk and genetic susceptibility.

bioRxiv · Oct 24, 2018 · PreprintSystems Biology