High-resolution transcriptomic profiling of the heart during chronic stress reveals cellular drivers of cardiac fibrosis and hypertrophy
M. A. McLellan, D. A. Skelly, M. S. I. Dona, G. T. Squiers, G. E. Farrugia, T. L. Gaynor, C. D. Cohen, R. Pandey, H. Diep, A. Vinh, N. A. Rosenthal, A. R. Pinto
This study uses single-cell transcriptomics to identify cellular drivers of cardiac fibrosis and hypertrophy under chronic stress, revealing sex-specific fibrogenic cell responses.
bioRxiv · Nov 25, 2019Cell Biology