HDAC1 regulates the chromatin landscape to establish transcriptional dependencies in chronic lymphocytic leukemia
T.-h. Lai, H. G. Ozer, P. Gasparini, N. Giovanni, R. Destafano, J. Ravikrishnan, T.-l. Tsai, R. Lapalombella, J. Woyach, V. Puduvalli, J. Blachly, J. C. Byrd, D. Sampath
This study identifies HDAC1's role in establishing transcriptional dependencies in CLL by analyzing chromatin features and shows HDAC1 inhibition disrupts B-cell signaling and survival networks.
bioRxiv · Aug 3, 2020 · PreprintCancer Biology