Modeling of Aryl Hydrocarbon Receptor Pathway Intrinsic Immunometabolic Role using Glioblastoma Stem Cells and Patient-Derived Organoids
F. Watanabe, E. W. Hollingsworth, Y. Banasavadi-Siddegowda, J. M. Bartley, S. T. Sizemore, L. Yu, M. Pietrzak, P. Schiapparelli, V. Puduvalli, B. Kaur, A. Quinones-Hinojosa, J. Imitola
This study identifies AHR's role in regulating intrinsic immunity, proliferation, and migration in GBM stem cells and organoids, linking it to poor prognosis and suggesting it as a therapeutic target.
bioRxiv · Mar 17, 2022 · PreprintCancer Biology