Author

P. Gasparini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Klioussof· 1 shared A. L. B. Scott· 1 shared A. Lagana· 1 shared A. Magro· 1 shared C. M. Croce· 1 shared D. Perahia· 1 shared D. Sampath· 1 shared E. A. Philot· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBiophysics

A. Klioussof

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Unveiling Mutation Effects on the Structural Dynamics of the Main Protease from SARS-CoV-2 with Hybrid Simulation Methods

E. A. Philot, P. Gasparini, J. C. de Mattos, A. Magro, E. Torres-Bonfim, R. C. N. Quiroz, A. Klioussof, D. Perahia, A. L. B. Scott

This study uses hybrid simulation methods to analyze how mutations affect the structural dynamics of SARS-CoV-2 Mpro, identifying changes in stability and function across variants.

bioRxiv · Jul 17, 2021Biophysics

A concurrent canonical and modified miRNAome pan-cancer study on TCGA and TARGET cohorts leads to an enhanced resolution in cancer

R. Distefano, L. Tomasello, G. L. R. Vinciguerra, P. Gasparini, Y. Xiang, M. Bagnoli, G. P. Marceca, P. Fadda, A. Lagana, M. Acunzo, Q. Ma, G. Nigita, C. M. Croce

The paper analyzes miRNA modifications in cancer using TCGA and TARGET datasets, showing improved clustering and prognostic insights from combining canonical and modified miRNAs.

bioRxiv · May 18, 2021 · PreprintCancer Biology

HDAC1 regulates the chromatin landscape to establish transcriptional dependencies in chronic lymphocytic leukemia

T.-h. Lai, H. G. Ozer, P. Gasparini, N. Giovanni, R. Destafano, J. Ravikrishnan, T.-l. Tsai, R. Lapalombella, J. Woyach, V. Puduvalli, J. Blachly, J. C. Byrd, D. Sampath

This study identifies HDAC1's role in establishing transcriptional dependencies in CLL by analyzing chromatin features and shows HDAC1 inhibition disrupts B-cell signaling and survival networks.

bioRxiv · Aug 3, 2020 · PreprintCancer Biology