Improving the solubility of pseudo-hydrophobic Alzheimer's Disease medicinal chemicals through co-crystal formulation
A. Tse, I. Janilkarn-Urena, J. Lin, X. Chang, C. Efthymiou, A. Idrissova, M. Zhang, C. K. Williams, S. D. Magaki, H. V. Vinters, D. L. Davies, T. Gonen, H. Gukasyan, P. M. Seidler
This study shows that forming salts of dihydromyricetin (DHM) improves its solubility and inhibitory activity against Alzheimer's disease tau, suggesting potential for medicinal chemistry applications.
bioRxiv · Apr 25, 2023 · PreprintPharmacology & Toxicology