Author

C. K. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

H. V. Vinters· 3 shared S. D. Magaki· 2 shared A. C. Martini· 1 shared A. Idrissova· 1 shared A. Tse· 1 shared B. N. Dugger· 1 shared C. DeCarli· 1 shared C. Efthymiou· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPharmacology & Toxicology

H. V. Vinters

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Improving the solubility of pseudo-hydrophobic Alzheimer's Disease medicinal chemicals through co-crystal formulation

A. Tse, I. Janilkarn-Urena, J. Lin, X. Chang, C. Efthymiou, A. Idrissova, M. Zhang, C. K. Williams, S. D. Magaki, H. V. Vinters, D. L. Davies, T. Gonen, H. Gukasyan, P. M. Seidler

This study shows that forming salts of dihydromyricetin (DHM) improves its solubility and inhibitory activity against Alzheimer's disease tau, suggesting potential for medicinal chemistry applications.

bioRxiv · Apr 25, 2023 · PreprintPharmacology & Toxicology

Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels

D. R. Wong, S. D. Magaki, H. V. Vinters, W. H. Yong, E. S. Monuki, C. K. Williams, A. C. Martini, C. DeCarli, C. Khacherian, J. P. Graff, B. N. Dugger, M. J. Keiser

The paper develops a deep learning model to detect amyloid neuropathologies from whole slide images using coarse labels, achieving performance comparable to expert annotations.

bioRxiv · Jan 13, 2023Pathology

Exophers are components of mammalian cell neurobiology in health and disease

I. Siddique, J. Di, C. K. Williams, D. Markovic, H. V. Vinters, G. Bitan

This study identifies exophers in mammalian brains, showing they are involved in protein waste disposal and increase under proteostatic stress in Alzheimer's and tauopathy models.

bioRxiv · Dec 6, 2021 · PreprintCell Biology