Prolonging coagulant activity of factor Xa under hemophilic conditions by site-specific N-glycosylation of the surface-exposed autolysis loop
A. C. Bonde, J. Lund, J. J. Hansen, J. R. Winther, S. Zahn, P. Tiainen, O. H. Olsen, H. H. Petersen, J. R. Bjelke
This study shows that N-glycosylation of FX's autolysis loop reduces FXa activation but enhances procoagulant activity in plasma assays.
bioRxiv · Jul 1, 2021 · PreprintBiochemistry