Transcriptional reprogramming in fused cells is triggered by plasma-membrane diminution
D. Feliciano, I. Espinosa-Medina, A. Weigel, K. M. Milano, Z. Tang, T. Lee, H. J. Kliman, S. M. Guller, C. M. Ott, J. Lippincott-Schwartz
The paper shows that cell fusion triggers differentiation through plasma-membrane diminution, leading to transient cell starvation and activation of AMPK, which inhibits YAP1 and causes cell-cycle arrest.
bioRxiv · Nov 6, 2019 · PreprintCell Biology