Dual Functions of SPOP and ERG Dictate Androgen Therapy Responses in Prostate Cancer
T. Bernasocchi, G. El tekle, M. Bolis, A. Mutti, A. Vallerga, L. P. Brandt, F. Spriano, T. Svinkina, M. Zoma, V. Ceserani, A. Rinaldi, H. Janouskova, D. Bossi, M. Cavalli, S. Mosole, , J. P. P. Theurillat
This study shows that SPOP and ERG mutations in prostate cancer have opposing effects on androgen receptor signaling and therapy response.
bioRxiv · Jul 8, 2020Cancer Biology