T. Svinkina

Structural basis for recognition of unfolded proteins by the ER stress sensor ERN1/IRE1α

This study identifies a 7-residue motif in unfolded proteins recognized by IRE1LD, revealing how IRE1 detects misfolded proteins to trigger the UPR.

Dual Functions of SPOP and ERG Dictate Androgen Therapy Responses in Prostate Cancer

This study shows that SPOP and ERG mutations in prostate cancer have opposing effects on androgen receptor signaling and therapy response.

Split-TurboID enables contact-dependent proximity labeling in cells

Split-TurboID enables proximity labeling at organelle contact sites by splitting the TurboID enzyme and reconstituting it at these sites, identifying over 100 endogenous proteins.

Proteomics of protein trafficking by in vivo tissue-specific labeling

The paper develops an in vivo platform to study secreted protein trafficking between organs, identifies interorgan communication factors, and finds conserved adipokines affecting muscle activity.

CBL mutations promote activation of PI3K/AKT signaling via LYN kinase

The paper investigates how CBL mutations drive oncogenesis by enhancing LYN kinase activity and PI3K/AKT signaling, suggesting LYN inhibition as a therapeutic strategy.

UbiFast, a rapid and deep-scale ubiquitylation profiling approach for biology and translational research

UbiFast enables rapid, high-throughput ubiquitylation profiling of up to 10,000 sites from small tissue samples, with applications in cancer research.

Directed evolution of TurboID for efficient proximity labeling in living cells and organisms

The paper develops TurboID and miniTurbo, biotin ligase mutants with enhanced catalytic efficiency for proximity labeling in cells and organisms, significantly reducing labeling time and toxicity.