EP400NL is required for cMyc-mediated PD-L1 gene activation by forming a transcriptional coactivator complex
Z. Li, H. L. Fitzsimons, T. K. Hale, J. H. Park
The paper shows EP400NL forms a chromatin remodeling complex that activates PD-L1 gene expression via cMyc, suggesting it as a target for cancer immunotherapy.
bioRxiv · May 30, 2021 · PreprintCancer Biology