Author

T. K. Hale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. E. Rieffer· 1 shared E. Harjes· 1 shared G. B. Jameson· 1 shared H. L. Fitzsimons· 1 shared H. M. Kurup· 1 shared J. Filitcheva· 1 shared J. H. Park· 1 shared M. Bayarjagal· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. E. Rieffer

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

S. Harjes, H. M. Kurup, A. E. Rieffer, M. Bayarjagal, J. Filitcheva, Y. Su, T. K. Hale, V. V. Filichev, E. Harjes, R. S. Harris, G. B. Jameson

This paper identifies a structural basis for inhibiting APOBEC3A, a mutagenic enzyme in cancer, using a hairpin DNA inhibitor that blocks its activity in human cells.

bioRxiv · Feb 17, 2023Cancer Biology

EP400NL is required for cMyc-mediated PD-L1 gene activation by forming a transcriptional coactivator complex

Z. Li, H. L. Fitzsimons, T. K. Hale, J. H. Park

The paper shows EP400NL forms a chromatin remodeling complex that activates PD-L1 gene expression via cMyc, suggesting it as a target for cancer immunotherapy.

bioRxiv · May 30, 2021 · PreprintCancer Biology