J. H. Park

Glutamine addiction is targetable via altering splicing of nutrient sensors and epitranscriptome regulators

This study shows PRMT5 inhibition targets MNA neuroblastoma by altering splicing of nutrient sensors and epitranscriptome regulators, leading to growth inhibition and apoptosis.

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

This study identifies FASLG expression patterns and shows that FAS-L/FAS auto-regulation governs CAR-T and CAR-NK cell persistence, enhancing antitumor efficacy when FAS is inhibited.

Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability

This study shows that vitamin B2 deficiency impairs PPAR regulation of fasting glucose, and PPAR agonists can rescue this defect.

Enhanced production of natural shiga toxin by overexpressing A subunit of Stx2e in Stx2e-producing Escherichia coli isolated in South Korea

This study enhances Stx2e production in STEC 150229 by overexpressing the A subunit, resulting in higher cytotoxicity against Vero cells.

An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria

This study identifies PgfA as a periplasmic protein essential for asymmetric polar growth in mycobacteria by coordinating lipid trafficking and cell wall synthesis.

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

The paper reconstructs the evolutionary history of therapy-related myeloid neoplasms using chemotherapy-associated mutational signatures and identifies distinct mutational patterns linked to different chemotherapies.

Mistimed feeding disrupts circadian rhythms of male mating behavior and female preovulatory LH surges in mice

The cytokine receptor DR3 identifies and activates thymic NKT17 cells

This study identifies DR3 as a surface marker for thymic NKT17 cells and shows it activates these cells in vivo and in vitro.

EP400NL is required for cMyc-mediated PD-L1 gene activation by forming a transcriptional coactivator complex

The paper shows EP400NL forms a chromatin remodeling complex that activates PD-L1 gene expression via cMyc, suggesting it as a target for cancer immunotherapy.

Label-free three-dimensional analyses of live cells with deep-learning-based segmentation exploiting refractive index distributions

The paper develops a label-free 3D segmentation method using deep learning to analyze live cells and their organelles without exogenous labels.

Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities

A Mechanistic Modeling Framework Reveals the Key Principles Underlying Tumor Metabolism

This paper presents a mechanistic model of tumor metabolism that identifies key principles governing metabolic heterogeneity and plasticity in cancer cells.

Enabling out-of-clinic human immunity studies via single-cell profiling of capillary blood

The paper develops a platform for single-cell immune profiling using capillary blood to study gene expression variability across individuals and time.

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

The paper investigates how a common SLC39A8 variant affects brain metal transport and plasma glycosylation in schizophrenia, identifying manganese-related changes and potential biomarkers.

Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae

This study shows that CAT tail aggregation in yeast causes proteotoxicity and blocks degradation of incomplete polypeptides.

Innate immune recognition of a bacterial MAMP leads to conditional activation of pro- or anti-inflammatory responses

This study shows that flagellin, a bacterial MAMP, can trigger either pro- or anti-inflammatory responses depending on the tissue's physiological state and context.

Wnt signalling drives context-dependent differentiation or proliferation in neuroblastoma

This study identifies Wnt target genes in neuroblastoma and shows Wnt signalling can drive differentiation in some cell lines and proliferation in others.