Regulatory role of cholesterol in modulating actin dynamics and cell adhesive interactions in the trabecular meshwork
T. Wang, H. R. Kimmel, C. Park, H. P. Ryoo, J. Liu, G. Underhill, P. P. Pattabiraman
This study investigates how cholesterol affects actin dynamics and cell adhesion in trabecular meshwork cells, showing that cholesterol modulates PIP2 levels and integrin distribution, thereby influencing cell stiffness and intraocular pressure.
bioRxiv · Feb 2, 2024 · PreprintCell Biology