J. Liu

Comprehensive profiling of antibiotic resistance, virulence genes, and mobile genetic elements in the gut microbiome of Tibetan antelopes

This study profiles antibiotic resistance, virulence genes, and mobile genetic elements in Tibetan antelope gut microbiomes, identifying species-specific resistance and potential human pathogen strains.

Modifications to the gut microbiome alter bone matrix proteomics and fracture toughness at the cellular scale

This paper shows that altering the gut microbiome changes bone matrix proteomics and reduces fracture toughness, with micropillar splitting as a precise method to measure these effects.

In vitro multi-assay cytotoxicity assessment of iron oxide nanoparticles on neural cells and addressing spectrophotometric interference

This study evaluates methods to address spectrophotometric interference in cytotoxicity assays of iron oxide nanoparticles on neural cells, finding that Resazurin with fluorometric readout is least affected by interference.

Super-Enhancer Driven ZFP36L1 Promotes PD-L1 Expression in Infiltrative Gastric Cancer

This study identifies ZFP36L1, driven by a super-enhancer, as a key regulator of PD-L1 expression in infiltrative gastric cancer, contributing to immune escape.

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Deletion of the endothelial glycocalyx component endomucin leads to impaired glomerular structure and function

This study shows that deleting endomucin in endothelial cells causes structural and functional issues in kidney glomeruli, including podocyte damage and albuminuria.

Spatial evidence of cryptic methane cycling and methylotrophic metabolisms along a land-ocean transect in a California coastal wetland

This study identifies cryptic methane cycling in coastal wetland sediments through geochemical and molecular analyses, showing methanogenesis and anaerobic methane oxidation co-occur with sulfate and iron reduction.

Systematically investigating and identifying bacteriocins in the human gut microbiome

The paper introduces IIBacFinder to identify unmodified class II bacteriocins in the human gut microbiome, showing their widespread distribution and biosynthetic potential.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

The West African lungfish secretes a living cocoon during aestivation with uncertain antimicrobial function

The paper investigates the structure and function of the aestivation cocoon in West African lungfish, finding no antimicrobial activity in the cocoon tissue.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

The Mammalian KU70 C-terminus SAP Domain Is Required to Repair Exogenous DNA Damage

This study shows that the KU70 SAP domain is essential for repairing exogenous DNA damage but not for V(D)J recombination or development.

EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancer

EstroGene2.0 is a multi-omic database that compiles data on estrogen receptor responses and resistance in breast cancer, revealing diverse transcriptomic changes and identifying key targets.

Cmai: Predicting Antigen-Antibody Interactions from Massive Sequencing Data

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

CREEPING STEM1 Regulates Directional Auxin Transport for Lodging Resistance in Soybean

This study identifies the CS1 gene in soybean, which regulates directional auxin transport and enhances lodging resistance, improving yield under high planting density.

Unveiling the Power of PROTAC Valency: Navigating Cell Type-Specific Hook Effects

The paper evaluates the impact of PROTAC valency on hook effects, showing that trivalent PROTACs do not eliminate the hook effect but may alter its dynamics.

Entropy Changes in Water Networks Promote Protein Denaturation

This study identifies entropy changes in water networks as a mechanism for ion-induced protein denaturation, revealing an 'inverse hydrophobic effect' that promotes unfolding.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

Distribution, Prevalence of Non-Tuberculous Mycobacteria in Hainan Island and Antibiotic Resistance of Mycobacterium abscessus

This study maps NTM distribution and antibiotic resistance in Hainan Island, identifying key species and resistance patterns to inform regional surveillance and treatment.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

Differences in systemic immune parameters in individuals with lung cancer according to race

The paper compares systemic immune parameters between Black and White lung cancer patients, finding significant differences in cytokine levels and immune cell populations.

Neural Decoding and Feature Selection Techniques for Closed-Loop Control of Defensive Behavior

This paper decodes defensive behaviors from LFP signals in rats using feature selection and machine learning, finding that high-gamma power and inter-regional connectivity are most informative.

Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma

This study shows that combining FACT and BET inhibition disrupts oncogenic transcription and extends survival in Diffuse Midline Glioma models.

Observation of Higher-Order Assemblies Controlled by Protein One-dimensional Movement

The paper investigates how MDA5 CARDs assemble and interact with LGP2 through one-dimensional movement along dsRNA to regulate immune response.

Negative Synergistic Effects of Drought and Heat During Flowering and Seed Setting in Soybean

This study examines the combined effects of drought and heat on soybean physiology, yield, and gene expression during flowering and seed setting, finding that combined stress has more severe negative impacts than individual stresses.

The Effects of Functional Training on Muscle Strength in Athletes: A Meta-Analysis

This study evaluates functional training's impact on athlete muscle strength compared to traditional resistance training, finding moderate to large effects on maximum strength, power, and muscle endurance.

Nanoclustering and signaling of KRAS G12C and KRAS G12D respond to lipid acyl chain remodeling in an allele-specific manner

This study shows that KRAS G12C and G12D mutants respond differently to lipid acyl chain remodeling, affecting their nanoclustering and signaling activities.

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

Genetically Encoded FRET Biosensor for Live-cell Visualization of Lamin A Phosphorylation at Serine 22

This paper develops a FRET-based biosensor to visualize lamin A phosphorylation at Serine 22 in live cells, revealing its dynamics during the cell cycle and its role in nuclear envelope breakdown.