H. Rieger

Amoeboid Cell Migration through Regular Arrays of Micropillars under Confinement

This study investigates how HL-60 cells' migration and search efficiency are affected by pillar density and confinement in microfluidic environments.

Stochastic model of T Cell repolarization during target elimination (II)

This paper uses a computational model to analyze T cell MTOC repositioning dynamics during immunological synapse interactions, showing stochastic behavior and dependence on molecular mechanisms.

Migration of Cytotoxic T Lymphocytes in 3D Collagen Matrices

This study investigates the migration patterns of CD8+ T cells in 3D collagen matrices, identifying three motility types and proposing a two-state model to explain their movement through ECM.

Stochastic model of T Cell repolarization during target elimination (I)

The paper develops a stochastic model to explain T cell re-polarization during target elimination, showing that capture-shrinkage dominates over cortical sliding when MTOC and IS are initially opposed.

Fine-grained simulations of the microenvironment of vascularized tumours

The paper introduces a computational tool to study the ecology and evolutionary dynamics of the tumour microenvironment and reports findings on its role in generating heterogeneity and drug resistance.

Dynamic vessel adaptation in synthetic arteriovenous networks

The paper applies an adaptation algorithm to synthetic arteriovenous networks and finds they do not follow Murray's law, suggesting potential implications for vascular tumor signaling.

Tumorcode - A framework to simulate vascularized tumors

The paper introduces Tumorcode, a simulation framework for vascularized tumors, combining existing models into a multi-scale approach and releasing the code for public use.

Spatial cytoskeleton organization supports targeted intracellular transport

The paper models intracellular transport efficiency using a random velocity model with intermittent arrest states, showing that spatial cytoskeleton organization enhances transport efficiency for specific tasks.