Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis
D. Kim, T. Horimatsu, M. Ogbi, B. Goo, H. Shi, P. Veerapaneni, R. Chouhaita, M. Moses, R. Prasad, T. W. Benson, R. Harb, G. Aboud, H. Sellers, S. Haigh, D. J. R. Fulton, , H. W. Kim
This study shows that disrupting soluble epoxide hydrolase (sEH) in the liver prevents abdominal aortic aneurysm (AAA) formation by reducing inflammatory factors like C3 and SAA.
bioRxiv · Jul 10, 2023 · PreprintPharmacology & Toxicology