Liver X Receptor; Controls Hepatic Stellate Cell Activation via Hedgehog Signaling
L. Zhong, B. Ning, X. Du, H. Shengjie, C. Cai, Y. Zhou, L. Deng, W. Shen
This study shows that LXRβ suppresses hepatic stellate cell activation via inhibition of Hedgehog signaling, offering a potential therapeutic target for liver fibrosis without causing liver steatosis.
bioRxiv · Jan 8, 2021 · PreprintCell Biology