SIX4 Controls STING Expression Enhancing anti-PD-1 Efficacy
B. Liang, E. H. Zhang, Z. Ye, H. Storts, W. Jin, X. Zheng, O. Zaleski, X. Xing, J. J. Wang
This study identifies SIX4 as a regulator of STING expression in colon cancer, showing it enhances anti-PD-1 therapy efficacy by promoting STING activation and CD8+ T-cell infiltration.
bioRxiv · May 26, 2023 · PreprintCancer Biology