X. Zheng

Vaccination by single dose sporozoite injection of blood stage attenuated malaria parasites

The paper identifies slow-growing, avirulent malaria parasite mutants that protect against disease after challenge with wild-type parasites.

The minimal SUF system can substitute for the canonical iron-sulfur cluster biosynthesis systems by using inorganic sulfide as the sulfur source.

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

Rapid High-Throughput Isolation and purification of Chicken Myoblasts Based on Deterministic Lateral Displacement Microfluidic Chips

This study develops a microfluidic platform for isolating chicken myoblasts using deterministic lateral displacement, achieving 80% recovery and 99% purity.

Fertilization-induced synergid cell death by RALF12-triggered ROS production and ethylene signaling

This study identifies RALF12-triggered ROS production and ethylene signaling as mechanisms causing synergid cell death during fertilization in maize.

Inducible deletion of Ezh2 in CD4+ T cells inhibits kidney T cell infiltration and prevents interstitial nephritis in MRL/lpr lupus-prone mice

Primary oocytes with cellular senescence features are involved in ovarian aging in mice

This study shows that senescent primary oocytes contribute to ovarian aging in mice, and their removal improves fertility and follicle numbers.

The trade-off between individual metabolic specialization and versatility determines the metabolic efficiency of microbial communities

This study shows that microbial communities with metabolic redundancy outperform both specialized and division-of-labor systems in naphthalene degradation.

Biosynthesis of the proteins containing neurotoxin β-N-methylamino-L-alanine in marine diatoms

This study investigates how iron limitation increases BMAA-containing protein production in marine diatoms and identifies cysK as a key enzyme in BMAA biosynthesis.

Comprehensive Multi-Omic Analysis Reveals Distinct Molecular Features in Early and Advanced Stages of Hepatocellular Carcinoma

This study uses multi-omic analyses to identify molecular features and biomarkers in early and advanced hepatocellular carcinoma stages.

Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

This study compares scholarly outputs from intramural and extramural NIH grants, finding extramural grants are more cost-effective for publications and citations, while intramural grants are better for clinical impact.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

This study transdifferentiates chicken fibroblasts into muscle cells with tunable fat deposition to create cultured meat mimics with controllable intramuscular fat content.

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

Zaxinone Synthase overexpression modulates rice physiology and metabolism, improving growth and productivity under normal and low phosphate supply

This study shows that overexpressing Zaxinone Synthase in rice increases zaxinone levels, enhances growth, and improves phosphate uptake, leading to higher grain yield.

ULK1-dependent phosphorylation of PKM2 antagonizes O-GlcNAcylation and inhibits the Warburg effect in breast cancer

This study identifies ULK1-mediated phosphorylation of PKM2 that inhibits O-GlcNAcylation and reduces the Warburg effect in breast cancer.

Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism

This study shows that sepiapterin reprograms M2-type tumor-associated macrophages in HER2+ breast tumors to M1-type by modulating arginine metabolism, enhancing immunotherapy response.

Pathogen lifestyle determines host genetic signature of quantitative disease resistance in oilseed rape (Brassica napus)

The paper uses associative transcriptomics to identify host genetic loci associated with quantitative disease resistance in oilseed rape to four fungal pathogens, finding that resistance depends on pathogen lifestyle rather than broad-spectrum resistance.

Unique T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort

This study identifies T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort using mass cytometry and random forest analysis.

Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

Trophic diversity and evolution in Enantiornithes: a synthesis including new insights from Bohaiornithidae

This paper analyzes the ecological diversity and evolution of Enantiornithes by introducing new data on Bohaiornithidae and integrating it with existing data on other enantiornithine families.

Potency of CRISPR-Cas Antifungals Is Enhanced by Co-targeting DNA Repair and Growth Regulatory Machinery at the Genetic Level

This paper demonstrates that co-targeting essential and DNA repair genes enhances CRISPR-Cas antifungal efficacy in yeast, outperforming single-target approaches.

A Gpr35 tuned gut-brain metabolic axis regulates depressive-like behavior

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

SIX4 Controls STING Expression Enhancing anti-PD-1 Efficacy

This study identifies SIX4 as a regulator of STING expression in colon cancer, showing it enhances anti-PD-1 therapy efficacy by promoting STING activation and CD8+ T-cell infiltration.

Mammalian Esophageal Stratified Tissue Homeostasis is Maintained Distinctively by the Epithelial Pluripotent p63+Sox2+ and p63-Sox2+ Cell Populations

This study identifies two distinct cell populations, p63+Sox2+ and p63-Sox2+, that maintain esophageal tissue homeostasis through different roles in stemness, differentiation, and damage repair.

Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching

This study identifies how bacterial contact triggers polar plug disintegration in whipworm eggs, facilitating larval hatching through chitinase activity rather than bacterial enzymes.

A toxic ankyrin cysteine protease effector RipBH of brown rot triggered autophagy-associated cell death

The paper identifies RipBH, a virulent type III effector from Ralstonia solanacearum, which induces autophagy-associated cell death and is essential for potato brown rot pathogenesis.

The significant yet short-term influence of research covidization on journal citation metrics

This study examines how publishing COVID-19 papers affected journal citation metrics, finding early entrants gained citation premiums that declined over time.

Multi-omic dissection of ancestral heat stress memory responses in Brachypodium distachyon

The paper investigates how repeated heat stress affects gene regulation in Brachypodium distachyon, identifying long noncoding RNA and miRNA roles in stress memory and resilience.

Esm-1 mediates transcriptional polarization associated with diabetic kidney disease

This study identifies Esm-1 as a marker and mediator of transcriptional polarization in diabetic kidney disease using single-cell and bulk transcriptomic data.