Characterization of the prion protein binding properties of antisense oligonucleotides
A. G. Reidenbach, E. V. Minikel, H. T. Zhao, S. G. Guzman, A. J. Leed, M. F. Mesleh, H. B. Kordasiewicz, S. L. Schreiber, S. M. Vallabh
This study examines the binding and antiprion properties of antisense oligonucleotides (ASOs) targeting prion protein (PrP), finding that sequence-independent binding and aggregation occur, but only PrP-lowering ASOs are effective in vivo.
bioRxiv · Nov 7, 2019Biochemistry